Grow Diffraction-Ready protein crystals with just nanovolume drops of protein solution. The MPCS uses technology that generates up to 800 experiments in one CrystalCard using every nanoliter of the protein sample - no dead volume! Sparse matrix and optimization experiments are generated automatically on-chip without the hassle of pipetting screens. Crystals are Diffraction-Ready: simply loop them out of the CrystalCard or analyze via in-situ X-ray diffraction.
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Protein crystallization experiments in the form of aqueous drops called "plugs" forming at the 3 1 mixer junction in an MPCS CrystalCard.
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The MPCS produces crystals that are Diffraction-Ready - large enough for traditional X-ray diffraction experiments and able to be harvested from the CrystalCard. |
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MPCS Advantages
- Low sample volume: 5-10 nL/experiment; up to 800 experiments / 4 uL protein
- No dead-volume! No loss of protein sample
- Enables systematic assessment of optimal protein 'crystallization slot' through optimization screens
- Crystals directly amenable to X-ray diffraction experiments with standard equipment
- Crystals can be readily extracted for traditional cryo-preservation
- Low cost per experiment
Reference: Gerdts et. al. Acta Cryst. (2008). D64, 1116-1122
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| Now taking orders...MPCS™ Plug Maker™ |
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